Soteria Biotherapeutics, Inc.

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Organization Description

Soteria is developing a next generation of conditionally active bispecific t-cell engaging antibodies to treat cancer patients with solid tumors. Soteria’s highly innovative T-LITETM platform provides small molecule-dependent activation of bispecific antibody therapies, enabling safer and more efficacious treatments through pulsatile activity, reduced side effects and higher dosing. T-LITEs incorporate a small molecule-controlled switch into a conventional bispecific t-cell engaging antibody which enables precise on/off control over the timing and magnitude of redirected T-cell cytotoxic activity. Soteria was founded in 2018 with technology licensed from UC San Francisco.

Program Information

The student will be measuring expression of potential immuno-oncology target proteins expressed on the surface of a variety of human cells, including adult intestinal stem cells. These target proteins are of interest because they are also expressed on many human cancers. The student will culture primary human intestinal stem cells and human cancer cells. She will measure the expression of the target proteins using flow cytometry. She will also measure the cytotoxicity of these cells when they are treated in a co-culture system with human T cells and immuno-oncology drugs directed against the target proteins.

The student will develop competency in several key laboratory skills related to immuno-oncology drug discovery. These include sterile tissue culture of mammalian cells, staining cells for flow cytometry, operating a flow cytometer, performing serial dilutions for high-throughput plate-based assays, safely handling biosafety level 2 tissue, and setting up co-culture assays. Additionally, she will learn to independently analyze and present her data, practice receiving and addressing scientific feedback, and the biology around her specific protein targets and cell types.

Health & Safety

Soteria requires all lab-facing employees to complete a 6-hour live instruction safety seminar covering OSHA regulations, laboratory safety, ergonomics, and workplace emergencies. This training is required to be repeated annually from the date of employment.
Additional requirements and/or considerations
  • Computer Literacy
  • Health Check/Screening (e.g. temperature screening, COVID-19 test)
  • Must be 18 or older
  • TB Test
Address 
953 Indiana Street
San Francisco, CA 94107
United States
Website:
https://www.soteriabiotherapeutics.com/
Student Contact 
Name
Erin Simonds
Job Title
Director, Immuno-Oncology
Phone
(415) 503-9226 Ext. 
Email
erin@soteriabiotx.com
Program(s) 
Internship
Organization type 
Science, Technology or Engineering (Private/For-profit)
Focus Population(s)
Non-specific/any population
Focus Area(s)
Health & Medicine, Research and Development, Science or Technology
Hours of operation 

Mon-Fri, 9am-5pm

Maximum students 
2